Dr. Frédéric Coutrot
Institut des Biomolécules Max Mousseron (IBMM)UMR 5247 Cnrs-UM1-UM2
Université de MontpellierBâtiment de Recherche 17
Place Eugène Bataillon, case courrier 1706
34095 Montpellier cedex 5, France
Tél.: (00 33) (0)4 67 14 38 43
Fax: (00 33) (0)4 67 63 10 46
The city of Montpellier is located in the south of France, closed to the mediterranean sea and can be reached from Paris in 3h30 by TGV train. Its sweet climate, its cultural and economical dynamisms, as well as its student life make of Montpellier a very attractive place to settle.
The SMARTeam publishes a review that describes synthetic challenges in post-interlocking modifications, for which the mechanical bond plays a fundamental role in the strategy employed. Opportunities brought by the mechanical bond to obtain molecules that would not be obtained the same way from non-interlocked precursors are also exemplified.
Challenges and Opportunities in the Post‐Synthetic Modification of Interlocked Molecules
P. Waelès, M. Gauthier and F. Coutrot, Angew. Chem. Int. Ed. 2021, 60, 16778-16799
In collaboration with teams from Bordeaux and Munich, the SMARTeam publishes a new supramolecular architecture, named Foldarotaxane, in which a molecular axle is surrounded by a macrocycle and wrapped by a helix. In this article - deemed "hot paper" by the editor - we highlight how the localization of the macrocycle along the threaded axle - controlled by molecular machinery - tremendously alters the affinity of the helix for the rotaxane. Conversely, the very high affinity of the helix for the axle allows for the compartmentalization of the rotaxane, displacing the macrocycle around a region of the axle for which it has less affinity.
Interplay Between a Foldamer Helix and a Macrocycle in a Foldarotaxane Architecture
M. Gauthier, V. Koehler, C. Clavel, B. Kauffmann, I. Huc, Y. Ferrand et F. Coutrot, Angew. Chem. Int. Ed. 2021, 60, 8380-8384.
The SMARTeam is located in the University of Montpellier (France). It is part of the institute of Biomolecules Max Mousseron (UMR Cnrs 5247). Our current research projects mainly concern the synthesis and the studies of original molecules, based on supramolecular or interlocked architectures (peptido and glycorotaxanes, lassos, double-lassos, molecular muscles), aimed to be used from the material (polymers) to the medicinal field (recognition, targeting, prodrugs, probes, diagnosis, ...). We are particularly interested in new conceptual approaches using Molecular Machines.
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